A search of the GenomRNAi database determined that linked proteins IK (IK cytokine), WD repeat domain 12, dyskerin pseudouridine synthase 1, and adenylosuccinate lyase (ADSL) in the green region of Figure 9A shared similar annotations and functioned to decrease expression of NF‐κB or IL‐8,67 which are related to inflammation.44, 45 Hence, further analysis of these linked proteins may help explain differential mechanisms between HP‐PRRSV and AP‐PRRSV infection. This evidence concerns the gene CXCL8 and infection.