CREB‐binding protein (CREBBP) is composed of double‐stranded RNA‐activated transcription factor with IRF‐3, and double‐stranded RNA‐activated transcription factor is activated in many virus‐infected cells to promote apoptosis.81, 82 CREBBP may interact with human herpes virus 8 vIRF‐1, which could inhibit the binding of CREBBP to IRF‐3.83 Our results showed that IRF‐3 abundance was tenfold lower in the HP‐PRRSV than the AP‐PRRSV group, which we proposed was a protective mechanism of PRRSV to escape from host immunity and ensure survival after viral infection. This evidence concerns the gene IRF3 and viral infectious disease.