There would also appear to be a dearth of data investigating TNFR activity in other chronic neurodegenerative diseases, although levels of TNFR1 and TNFR2 activity are abnormal in the animal model of multiple sclerosis (MS), described as experimental autoimmune encephalomyelitis [152]. The gene discussed is TNFRSF1A; the disease is myeloid sarcoma.