STAT3 and Alzheimer disease: It has been reported that several agents such as thiacremonone (Song et al. 2014; Yun et al. 2016), 2,4-bis(p-hydroxyphenyl)-2-butenal (Jin et al. 2013), ent-Sauchinone (Song et al. 2014), 4-O-Methylhonokiol (Lee et al. 2012b) decreased β-secretase activity through the inhibiting STAT3 activity in AD model.