The relatively recent discovery of up-regulated, inducible, NF-kB-regulated miRNAs in the human CNS and altered miRNA-mRNA coupled networks in AD brain is revealing an entirely new layer of post-transcriptional gene control in sporadic AD – and together this has greatly expanded our perception, knowledge and understanding of the complexity and dynamics of pathogenic gene regulation in the human CNS [25–30]. Here, NFKB1 is linked to Alzheimer disease.