After study of routine hematoxylin and eosin stained slides, the cases were scrutinized for PSP and other neurodegenerative diseases using immunohistochemical stains for abnormal tau, alpha-synuclein, synaptophysin and amyloid aggregates in Patient 1 and for abnormal tau and amyloid in Patient 2. The gene discussed is MAPT; the disease is neurodegenerative disease.