When insulin resistance is defined as HOMA-IR >2, the ALT/AST ratio remained one of the best markers for IR in the Chinese population with OR 1.89 (1.70–2.11) in non-central obesity and 2.02 (1.81–2.25) in central obesity (all P < 0.001) after adjusting for all possible confounders (Table 4). This evidence concerns the gene GPT and Insulin resistance.