The literature regarding the possible role of polyfunctional CD4+ T cells in mediating vaccine-induced protection for TB has primarily investigated those cells co-producing IFN-γ, TNF-α, and IL-2, hereafter, we will refer to as “polyfunctional CD4+ T cells.” There is substantial evidence derived from study of murine TB models and humans that all three of these cytokines are necessary for the control of Mtb infection. Here, TNF is linked to tuberculosis.