HP and coronary artery disorder: So, the significant reduction in the abundance of Faecalibacterium prausnitzii and in the predicted proportion of genes related to the butanoate metabolism that we found in the CAD-DM2 patients when compared with CAD-NDM2 may partially explain the significantly lower levels of zonulin and serum IL-10 and the significantly higher levels of serum IL-1β and plasma TMAO in the CAD-DM2 patients.