Moreover, the significant reduction in the abundance of Faecalibacterium prausnitzii and Bacteroides fragilis found in CAD-DM2 patients was associated with the decrease in the release of the anti-inflammatory and anti-atherogenic cytokine IL-10 and the peripheral FOXP3 mRNA expression, respectively, both implicated in the development and function of Treg cells. This evidence concerns the gene IL10 and coronary artery disorder.