Between WMH group and non-WMH group, there was no significant difference in gender, education, WBC, fasting blood glucose, HbA1C, TC, HDL-C, LDL-C, ApoA, and ApoB (p > 0.05, Table 4), while there was significant difference in age, hypertension, diabetes mellitus, hyperlipidemia, NIHSS score (NIHSS > 3), previous history of stroke, number of lacunes, ventricle-to-brain ratio and TG (p < 0.05, Table 4). The gene discussed is APOB; the disease is Hypertension.