SYVN1 and central precocious puberty: In this study, by utilizing METH-induced CPP model, we tested this hypothesis by investigating the role of ERAD in the regulation of GABAAα1 expression, and found that Synovial apoptosis inhibitor 1 (SYVN1), the ERAD E3 ubiquitin ligase, modulated the downregulation of GABAAα1 protein associated with METH CPP.