The high AUC values that we obtained on the Proseek® plates (0.88–1.0) comparing sera from early and late stage serous ovarian cancer patients to sera from healthy or benign ovarian disease, confirm the extensive literature of the past two decades on the usefulness of CA125 as an ovarian cancer biomarker [7–9]. The gene discussed is MUC16; the disease is ovarian serous adenocarcinoma.