In addition, cardioprotective effects of statins in an angiotensin II (Ang II)-induced cardiac hypertrophy and fibrosis mice model10 and the renoprotective effects of statins in gentamicin-induced nephropathy in rats through the attenuation of oxidative stress leading to improving renal Oat3 and renal function11 have been reported by our team. This evidence concerns the gene AGT and fibrosis.