We constructed miR-gene regulatory networks with sequencing data from breast invasive carcinoma patients, using a network approach we found the highly studied involvement of miR-200 in the acquisition of epithelial and mesenchymal traits through EMP in breast cancer, and suggested the participation of other miRs such as the miR-199 family members and the DLK1-DIO3 cluster. The gene discussed is DIO3; the disease is breast cancer.