SMAD3 and coronary artery disorder: By using imputation based on the 1000 Genomes Project, a genome-wide association study (GWAS) meta-analysis of the data from the CARDIoGRAMplusC4D Consortium indicated that the rs56062135 single nucleotide polymorphism (SNP) in the intron region of the SMAD3 gene is associated with coronary artery disease (CAD)7.