Subjects with the CC genotype of SMAD2 rs11082639 and the G allele of TGFBR2 rs3773651 also had a 5.85-fold higher risk of MetS than those with the T allele of SMAD2 rs11082639 and the AA genotype of TGFBR2 rs3773651 (Table 5). The gene discussed is SMAD2; the disease is metabolic syndrome.