Thus, we hypothesized that TGF-β signaling pathway-associated genes, namely SMAD2, SMAD3, SMAD4, TGFB1, TGFB2, TGFB3, TGFBR1, and TGFBR2 genes, may be linked to MetS. The gene discussed is TGFBR1; the disease is metabolic syndrome.