As demonstrated in Table 2, for the SMAD2 rs11082639 SNP, an increased risk of MetS was observed among subjects with MetS and those without MetS after adjustment for covariates such as age and sex for genetic models, including the additive model (odds ratio [OR] = 1.66; 95% confidence interval [CI] = 1.32–2.08; P = 1.4 × 10−5) and recessive model (OR = 2.82; 95% CI = 1.80–4.43; P = 6.6 × 10−6). The gene discussed is SMAD2; the disease is metabolic syndrome.