Our analysis revealed that subjects with the CC genotype of SMAD2 rs11082639 and the AA genotype of TGFBR2 rs3773651 had a 2.5-fold higher risk of MetS than those with the T allele of SMAD2 rs11082639 and the AA genotype of TGFBR2 rs3773651 (Table 5). This evidence concerns the gene SMAD2 and metabolic syndrome.