Other highly expressed markers play roles in nutrient uptake (CD71, CD220)47,48, detection of mitogenic as well as apoptotic signals (CD140A, CD140B, CD221)49, migration of neural crest cells during embryological development (CD184)50–53 or are strongly associated with tumor invasion (CD56, CD97, CD146, CD147, CD166)41,54,55. This evidence concerns the gene IGF1R and neoplasm.