INSR and neoplasm: Other highly expressed markers play roles in nutrient uptake (CD71, CD220)47,48, detection of mitogenic as well as apoptotic signals (CD140A, CD140B, CD221)49, migration of neural crest cells during embryological development (CD184)50–53 or are strongly associated with tumor invasion (CD56, CD97, CD146, CD147, CD166)41,54,55.