Seizures were particularly common in mice expressing mutant RHEB: whereas 20% (2/10) of mice expressing RHEB1-WT developed epilepsy, all (7/7) mice expressing RHEBp.P37L and 83% (5/6) of mice expressing RHEBp.S68P developed spontaneous seizures (Fig. 4d). Here, RHEB is linked to epilepsy.