Additionally, BPA has also been positively correlated with decreased semen quality and male infertility, for which induction of germ cell apoptosis is considered a primary contributing factor [78], reduced sperm concentration, total sperm count, vitality and motility [79], and alterations in laboratory parameters that may contribute to male infertility such as, prolactin, estradiol and sex hormone-binding globulin (SHBG) [80]. The gene discussed is SHBG; the disease is male infertility.