ESR1 and ovarian carcinoma: Among the ER-dependent effects, we identified additive interactions on estrogen receptor activation and estrogen-regulated pS2 gene transcription in MCF7 cells [97], in Ovarian cancer cell line BG-1 suppression of BPA Estrogen receptor alpha (ERα) mediated cell proliferation induced by genistein [39] and ER α and ER β activation additive effects in MCF7 and HeLa cells [38].