DISC1 and schizophrenia: For instance, neurons from schizophrenia patients with mutated DISC1, which is thought to have a neurodevelopmental dimension to its pathology (Walsh et al, 2008), show downregulation of metabolic pathways and LAMA2, a gene in which de novo mutations have been identified in cases of sporadic schizophrenia (Xu et al, 2012) (Fig 6D and Appendix Fig S8).