LRRK2 and Parkinson disease: To determine if this localization was maintained in differentiated progeny, we next studied NSCs with mutant LRRK2 and observed increased expression of dysregulated genes in the cerebellum (Seidel et al, 2017), mesencephalon, and myelencephalon (Qamhawi et al, 2015), where significant PD pathology is observed, particularly in the substantia nigra pars compacta, in the prenatal and adult brain heatmaps.