Rare encountered CFDs, known as “rare” bleeding disorders (RBDs), comprise deficiency of fibrinogen, factor (F) II, FV, combined FV and FVIII, FVII, FX, FXI, FXIII, and vitamin K-dependent factors, which are transmitted autosomal recessive with the exception of some cases of FXI deficiency and dysfibrinogenemia that may be autosomal dominant. This evidence concerns the gene F5 and hyperinsulinemic hypoglycemia, familial, 4.