In patients with RBD, 5 patients with FVII deficiency were given prophylaxis of recombinant-activated factor VII (rFVIIa) weekly or twice a week, 4 patients with FX deficiency was given prothrombin complex concentrate (PCC) twice a week, 3 patients with fibrinogen deficiency were given fibrinogen every 2 weeks, 1 patient with FV deficiency were given FFP weekly. This evidence concerns the gene F2 and hyperinsulinemic hypoglycemia, familial, 4.