As with the somatic 10398 A > G variant, the acquired ND4 11719 G > A variant reported in four of 10 metastatic [41] and a single primary PCa [39], is a known polymorphic back mutation defining the H5a1b and H27 European-predominant haplogroups from the original R0 (previously pre-HV haplogroup) defining 11719 A > G polymorphism. This evidence concerns the gene MT-ND4 and posterior cortical atrophy.