The other 12 somatic non-synonymous mutations predicted to have pathogenic potential impact the following genes: ND4 (3), CO1 (2), CYTB (2), ND5 (2), ND1 (1), ND2 (1) and ND4L (1), with all reported in primary PCa and one ND4 11351 G > A also within a single soft tissue metastasis. Here, MT-ND4 is linked to posterior cortical atrophy.