ZBTB16 and hepatocellular carcinoma: In early studies, PLZF was primarily linked to haematological malignancies, but it is now also implicated in various solid tumors (Table 1), including melanoma [26, 27], hepatocellular carcinoma [28], pancreatic cancer [29], colon cancer [30, 31], lung cancer [32], thyroid carcinoma [33], glioma [34] and PCa [5, 6, 35, 36].