The anti-tumorigenic role of miR-708-5p in prostate cancer was not solely due to CD44, as miR-708-5p also targets RAC-beta serine/threonine-protein kinase (AKT2), NNAT, and karyopherin importin subunit alpha-4 (KPNA4) in prostate cancer [160, 164, 165] (Figure 2A, 2C). This evidence concerns the gene KPNA4 and Familial prostate cancer.