Beyond the direct effect of KPNA4 suppression on prostate cancer cell growth, KPNA4 knockdown reduced M2 tumor-associated macrophage (TAM) infiltration into tumors in vivo by reducing chemokine (C-C motif) ligand 2 (CCL2) and chemokine (C-C motif) ligand 8 (CCL8) expression in prostate tumor cells [165]. This evidence concerns the gene CCL2 and Familial prostate cancer.