CD8A and cancer: Key insights on why these CD103+/CD141+ DCs display such unique function came from a recent work that used a mouse model of cancer to question which of the different tumor associated APCs (resident CD11b+, migratory CD11b+, CD8α+, CD103+ and macrophages) could phagocytose ovalbumin (OVA) and m-cherry from tumor cells, migrate to the draining LN and still be positive for m-cherry fluorescence, indicating the presence of the intact antigen.