CD8A and neoplasm: For example, mice bearing GL261 glioma tumors were treated with one intratumoral injection of an adenoviral vector encoding IFN-α followed by implantation of syngeneic bone marrow-derived DCs resulting in increased survival due to an antitumor immune response dependent on CD8+ T cells, and it was shown that the animals acquired a certain level of resistance against a second tumor challenge [338].