In another study with melanoma cells, IFN-β potency was also greater than IFN-α2 for induction of ISGs, like cytomegalovirus-induced gene 5 (CIG5/viperin), CIG49, ISG54, TLR3, CXCL10, TRAIL, as seen by microarray analysis of both WM9 and WM35 cell lines, while for the IFN-β-sensitive WM9 cell line, IFN-β also induced expression of SP100, tumor necrosis factor-stimulated gene 6 (TSG6), augmented in prostate carcinoma gene (AIPC), Cyclin-E, ubiquitin E2-like (UBEL-2) and ubiquitin-specific protease (USP18), as seen by RT-qPCR [104]. This evidence concerns the gene IFNB1 and melanoma.