Furthermore, the regulation of immunity in cancer by IFN-α/β also involves increased cytotoxic functions of NK cells [146], which are lymphoid cells that through a balance of activating (e.g., NKG2D) and inhibitory receptors (e.g, killer-cell immunoglobulin-like, KIR) can effectively kill tumor cells [175]. This evidence concerns the gene IFNA1 and neoplasm.