Regarding the immunomodulatory property of IFN-α, it was also observed that the gene transfer, alone or combined with other therapy approaches, lead to: (i) increased presence of infiltrating CD8+ and CD4+ T cells and decreased Foxp3+ cells in the tumor parenchyma and also augmented MHC-I expression on tumor cells [316]; (ii) enhancement of NK cell cytolytic activity [312] and (iii) increased presence of CD11c+ cells in regional lymph nodes [317]. This evidence concerns the gene CD4 and neoplasm.