Nevertheless, production of IFN-α by human pDCs can also be negatively regulated through the receptors BDCA2, NKp44 and ILT7, although only ILT7 has a known ligand, BST2 found on the cell membrane upon exposure to type I IFNs and also in a fraction of melanomas [27, 33]. The gene discussed is IFNA1; the disease is melanoma.