KMT2A and acute myeloid leukemia: Expression profiling of acute myeloid leukemia (AML) identified a set of seven miRNAs comprising miR-17-5p that allows discrimination of three common AML-causing chromosomal translocations with a diagnostic accuracy of > 94%, and is significantly overexpressed in MLL (mixed lineage leukemia) rearrangements, which causes particularly aggressive leukemia with poor prognosis [108].