PTEN and neoplasm: In addition, both miR-17-5p and miR-17-3p are abundantly processed from precursor miR-17 and have synergetic effects on developing HCC by binding different targets on different signaling pathways: miR-17-5p targets PTEN, one of the most frequently lost tumor suppressor in human cancers, while miR-17-3p represses expression of vimentin, an intermediate filament with the ability to modulate metabolism, and GalNT7, an enzyme that regulates metabolism of liver toxin galactosamine.