To justify miR-17-5p acts as tumor suppressor, a study shows that low expression levels of miR-17 results in cisplatin resistance of NSCLC by high expression of CDKN1A (cyclin-dependent kinase inhibitor 1A) and RAD21 (Rad21 homolog (Schizosaccharomyces pombe)) [83]. The gene discussed is RAD21; the disease is non-small cell lung carcinoma.