IFNB1 and neoplasm: The major population of TAMs is composed of CD163+ M2 polarized macrophages [12], and anti-tumor agents (e.g., IFN-α, IFN-β, or IFN-γ) could activate TAMs [10, 13], which, once activated, could increase serum soluble (s)CD163 [14] and release various autoimmune related chemokines such as CXCL5 [15, 16].