CADD522 treatment of ectopic RUNX2-expressing BC cells (T47D-RUNX2 and MCF7-RUNX2) resulted in a dramatic decrease of the promoter-luciferase (Luc) activities of RUNX2 downstream target genes such as MMP13 and VEGF (metastasis markers) (Figure 4A & 4B) and OC (osteogenesis marker) (Supplementary Figure 5A). The gene discussed is MMP13; the disease is breast cancer.