CASP3 and neoplasm: In both MMTV-PyMT mammary and PDX tumors, higher RUNX2 staining was observed in most of the tumor sections from CADD522-injected mice compared to vehicle control mice (Figure 9E & 9G, lower panel), but only negligible caspase-3 staining and no necrosis were observed in the tumor sections from vehicle control or CADD522-injected mice (data not shown), which suggest that CADD522 might delay detectable tumor growth in mice without inducing apoptosis.