LEF1 and cancer: We found that the expression levels of the genes in the Wnt/β-catenin signaling pathway, including APC, β-catenin, TCF7L1, TCF7L2, LEF1, MMP7, C-myc, C-jun, CYCLIND1 and GSK-3β, were remarkably higher in cancer than non-cancer tissues in the p.1125Val>Ala mutant FAP family members (Figure 1A, 1B).