PMS1 and hereditary nonpolyposis colon cancer: Other examples of connections between CRC and genomic variations include mutations in genes such as MSH2 [16], MLH1 [17], PMS1 [18], TGFBR2 [19] etc, which are associated with hereditary nonpolyposis colorectal cancer (HNPCC), and those in the MUTYH gene, which are associated with autosomal recessive adenomatous polyposis [20].