In conclusion, we found that the APC gene SNP rs11954856 was associated with CRC by increasing expression levels of genes in the Wnt/β-catenin signaling pathway in the CRC cancer patients, compared to the p.1125Val>Ala mutation in APC, which increased expression levels of not only all the genes downstream of APC in the Wnt/β-catenin signaling pathway in CRC but also GSK-3β upstream of APC. Recently, some researchers have found that the SNP rs11954856 is associated with the risk of ovarian and gallbladder cancers [48, 49]. This evidence concerns the gene APC and gallbladder cancer.