Although localization and degradation of β-catenin and the other target genes of the signaling were not investigated in detail, increased retinoid signaling appears to inhibit Wnt/β-catenin pathway and to be associated with suppression of hepatic fibrosis and NASH-related liver tumorigenesis in Lrat KO mice. This evidence concerns the gene LRAT and metabolic dysfunction-associated steatohepatitis.