In the present study, we examined the effects of endogenous HSC retinoid stores and activation of retinoid signaling on NASH and liver tumor development in wild-type and Lrat KO mice that were administered streptozotocin (STZ) and then fed a high-fat diet (HFD) to induce NASH and HCC. This evidence concerns the gene LRAT and metabolic dysfunction-associated steatohepatitis.