Overexpression or knockdown studies of HOXA11-AS or PADI2, as well as gain-/loss-of-function studies of miR-125a-5p, revealed a positive correlation between HOXA11-AS and PADI2 and a negative correlation with miR-125a-5p, confirming their involvement in the regulation of liver metastasis in CRC cell lines. The gene discussed is HOXA11; the disease is colorectal carcinoma.