Similarly, in SIRT1 knockout mice, although intake of HFD induced a higher level of glucose intolerance in SIRT1-/- mice than SIRT1+/- mice (Supplementary Figure 3A and 3E), there were no differences in the expression of macrophage marker genes epididymal fat between the two groups (Supplementary Figure 3F and 3G). Here, SIRT1 is linked to Glucose intolerance.