To obtain further insight of translational level of the expression of COL3A1, we observed the immunohistochemistry staining of COL3A1 in both normal bladder and bladder cancer in the Human Protein Atlas database and discovered that compared with normal bladder tissue, the expression of COL3A1 was significantly up-regulated in bladder cancer tissue. The gene discussed is COL3A1; the disease is urinary bladder carcinoma.