Here we aim to evaluate by mean of both immunohistochemial and morphometrical assay the density of mast cells positive to c-Kit receptor (c-Kit+ MCs), the density of MCs expressing tryptase (MCD-T) and microvessel density (MVD) in a series of 35 pancreatic ductal adenocarcinoma (PDAC) from patients underwent to up-front surgical treatment. The gene discussed is KIT; the disease is pancreatic ductal adenocarcinoma.