Although early detection of GC and metastasis is crucial to achieve better outcome for GC, conventional non-invasive serum tumor markers such as carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), and cancer antigen 19–9 (CA19-9) have poor diagnostic values for GC mainly due to their low sensitivities [2]. The gene discussed is MUC16; the disease is neoplasm.