Recent GWASes have found several novel loci located at chromosome 12q24, which covers the mevalonate kinase gene (MVK, also known as: MK; LRBP; MVLK; POROK3, Gene ID: 4598, HGNC ID: 7530), methylmalonic aciduria (cobalamin deficiency) cblB type gene (MMAB, also known as: ATR; cob; cblB; CFAP23, Gene ID: 362265, HGNC ID: 19331), all of which can affect HDL-C levels [18, 19]. Here, MVK is linked to Decreased circulating vitamin B12 concentration.