CD8A and diabetes mellitus: CD8 T cell depletion 2 days before the boost abrogated the ability of BiVax/IL2Cx to induce diabetes (Figure 3C) and mice vaccinated with an irrelevant peptide (pam-Ova257-264) with BiVax/IL2Cx, which generated a vast immune response (∼50% tetramer+ T cells in blood), did not develop diabetes (Supplementary Figure 2).