AKAP12 and neoplasm: Having shown in multiple systems that SSeCKS/AKAP12 loss in tumor cells promotes metastasis in xenograft and transgenic models, and that this correlates with more SSeCKS/AKAP12 downregulation in human metastases compared with primary-site tumors [1], we addressed whether the documented loss of SSeCKS/AKAP12 in TME also facilitates increased metastatic potential.