AR and obesity due to melanocortin 4 receptor deficiency: In the same line, though labmertianic acid (LA) is known to have anti-obesity [40], stress-protective [41], anti-allergic [42] and neurotropic [43, 44] activities, its other anti-cancer studies have not been reported except our group’s report on anticancer effect of LA via androgen receptor(AR) ablation [45] inhibition until now.