Here, LA cleaved PARP, caspase-3 and inhibited antiapoptotic proteins such as Bcl-2, Bcl-xL and also suppressed the expression of COX-2, PI3K, p-AKT and p-mTOR as survival pathway proteins in two HCC cells, implying LA induces apoptosis via inhibition of antiapoptotic and survival proteins. This evidence concerns the gene BCL2 and hepatocellular carcinoma.