Gao et al. discovered that NAC1 was upregulated in ovarian cancer tissues, and that highly expressed NAC1 decreases nuclear factor-κB phosphorylation (induced by the metastasis suppressor gene MKK4) and promotes Twist expression, which then inhibits E-cadherin expression and induces EMT in ovarian cancer cells; in their experiments the invasive and metastatic abilities of ovarian cancer cells were accordingly enhanced [30]. The gene discussed is MAP2K4; the disease is ovarian carcinoma.