In addition, there was no statistically significant association between the prognosis of CLL and SF3B1 mutation in small sample size subgroup, PFS HR=0.93(0.48-1.81) and OS HR=1.53(0.74-3.18), and this also could be found in PFS of PCR-based methods group. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.