Multivariate analysis showed mutant MTOR gene (hazard ratio [HR]:9.26, p= 0.002, 95% CI: 2.22 – 38.58), AJCC stages III (HR: 1.9, p= 0.013, 95% CI: 1.14 - 3.16), AJCC stages IV (HR: 2.15, p= 0.000, 95% CI: 1.40 - 3.30) and mutant CCND1 gene (HR: 5.71, p= 0.028, 95% CI: 1.21 – 27.0) were associated with the relapse of GC. Here, CCND1 is linked to gastric cancer.