In addition to the known AREs, we identified 17 previously-unknown putative NRF2-regulated genes – ABHD14B, ACOT13, ALDH3B1, ALDH6A1, ALDOC, CYP4F11, DSEL, HPSE, INSIG1, KYNU, LRP8, NAMPT, PDK1, PNPLA3, PPP1R3C, PTGES, and SLC27A5 – which are involved in different metabolic activities in cancer cells. This evidence concerns the gene HPSE and cancer.