The near complete inhibition in tumorsphere formation suggests that ESE-1, like other ETS factors, has a role in controlling ability of cells to initiate and maintain tumors and that knockdown of ESE-1 possibly inhibits the proliferation of tumor initiating cells in HER2+ cells similar to anti-cancer drugs, such as Lapatinib or Metformin [33, 34] along with other . This evidence concerns the gene ERBB2 and neoplasm.