NFKB1 and Familial prostate cancer: Notably, the ESE-1 promoter has NF-KB binding sites and, in prostate cancer cells, ESE-1 and NF-KB are involved in a positive feedback loop, whereby ESE-1 binds to ETS binding sites on the NF-KB promoter and thus induces genes that enhance the tumorigenic phenotype of LNCaP cells [48].