COMMD5 and nonpapillary renal cell carcinoma: We have no evidence that COMMD1 is involved in HCaRG/COMMD5 effects reported here as HCaRG overexpression in Renca cells did not modify COMMD1 expression, but we cannot exclude that HCaRG might interact with other members as it does with COMMD1 in ccRCC (Supplementary Figure 5A and 5B).