ERBB2 and cancer: The erythroblastosis oncogene B (ErbB) receptors such as epidermal growth factor receptor (EGFR/ErbB1/HER1) and ErbB2, also known as HER2 or p185c-neu, are implicated and overexpressed in the development of many types of cancer, and undergo several alterations in human cancers [7, 8].