Thus, our results suggested the indicative value of HMGB2, PDGFRA and HSD17B4 to be the important genes in pathogenesis of PCOS on one hand, and on another hand, the hypolipidemia drug detected from our network could provide more choices for treatment of disorders of lipid metabolism in obese PCOS women. Here, HMGB2 is linked to polycystic ovary syndrome.