The specificity of the EIF3D findings was further supported by testing the impact of knock-down of an additional potential target selected from the pathway analysis: GTP-binding protein Rheb (RHEB), not previously associated with BC, laying upstream of EIF3D and considered one of the key molecules activating the mTOR complex ([51–54]; Supplementary Figure 1). The gene discussed is EIF3D; the disease is breast cancer.