CTSE and breast cancer: Many of these proteins including annexin A10 (ANXA10) [40], HPGD [36], actinin alpha 4 (ACTN4) [42, 43], CTSE [47] and CDH13 [46] and a total of 21 others [including transforming growth factor-beta-induced protein ig-h3 (TGFBI), palladin (PALLD), adipogenesis regulatory factor (ADIRF), anterior gradient protein 2 homolog (AGR2), keratin type I cytoskeletal 19 (KRT19)] have already been associated with BC, when compared with a database on MIBC [56], serving as “positive controls” for the applied approach.