CTLA4 and cancer: Considering the severity of the disease, some novel therapies are currently investigated in clinical trials, including cancer immunotherapies targeting proteins such as programmed cell death protein 1 (PD-1), cytotoxic T-Lymphocyte associated protein 4 (CTLA-4) [8]; cell cycle checkpoint inhibitors targeting Aurora kinase A [9] and signal transduction inhibitors targeting fibroblast growth factor receptors (FGFR) [10].