The distribution of serum levels of top-ranked proteins (ADM, TRAP, GDF15, suPAR, REG4, TGFB1, sMICA, IL1RA, HE4, sHGFR, sVEGFA; see Table 1A), all found upregulated in MM, is shown in Figure 1. This evidence concerns the gene REG4 and Miyoshi myopathy.