The best triple-combinations for separating MGUS and MM were sMICA-ADM-GDF15 (Figure 6A) as well as the combination of sMICA-ADM-REG4, sMICA-suPAR-REG4, sMICA-suPAR-sHGFR, ADM-suPAR-REG4, TRAP-REG4-sHGFR (data not shown). The gene discussed is REG4; the disease is Miyoshi myopathy.