It has also been shown that Ezh2 directly regulates Egr1 in hematopoiesis, and that deletion of Ezh2 and the reactivation of genes repressed by it, including Egr1, converted a high-grade myeloid leukemia to a less aggressive myeloid neoplasia (MPN) [14, 15]. This evidence concerns the gene EZH2 and myeloproliferative disorder.