Parathyroid hormone related protein (PTHrP) is an important mediator of hypercalcemia and osteolytic bone loss through upregulation of RANKL whereas; the Dickkopf-WNT signaling pathway inhibitor 1 (DKK1) inhibits osteoblast bone formation, thus altering the bone resorption/bone formation balance of the bone microenvironment towards osteolytic bone loss. This evidence concerns the gene PTHLH and hypercalcemia disease.