We found that factors known to promote bone loss in solid and hematologic cancers (IL-6, MCP-1 and IL-3) were significantly elevated serum from Gzmb-HBZ mice compared to WT mice, indicating HBZ-mediated changes in cytokine secretion may directly or indirectly accelerate bone loss in this model. Here, IL3 is linked to hematopoietic and lymphoid cell neoplasm.