SLC16A3 and cancer: To avoid intracellular acidification and feedback inhibition of glycolysis, intracellular lactate homeostasis in both normal and cancer cells is maintained by members of the monocarboxylate transporter (MCT) family: MCT1 (solute carrier family 16 (monocarboxylate transporter), member 1) (SLC16A1), MCT2 (SLC16A7), MCT3 (SLC16A8) and MCT4 (SLC16A3) [3].