The variant in miR-612 has been previously demonstrated to increase the miRNA expression.37 We showed that the variant in miR-4707 does not influence the miRNA expression, but affects the binding of miR-4707 to one of its glaucoma-associated target genes, CARD10. Moreover, we identified 47 SNPs in miRNA-binding sites (within the 3′UTR of 21 genes) that are significantly associated with POAG endophenotypes. Here, CARD10 is linked to open-angle glaucoma.