CDKN2B and glaucoma: The CDKN2B gene encodes a cyclin-dependent kinase inhibitor and with its antisense (CDKN2B-AS1) lies in a well-known glaucoma-associated locus on Chr.9p21.5,6 The minor allele (G) at rs1063192 site is predicted to create a binding site for miR-323b-5p and the rs3217992 minor allele (T) is expected to disrupt the existing binding site of miR-138-2-3p within the 3′UTR of CDKN2B. Horswell et al.54 have shown that these miRNAs control both CDKNB2 mRNA and protein levels.