CAV2 and glaucoma: For example, the minor allele of rs1052990 in the 3′UTR of CAV2, a known gene for glaucoma, is predicted to disrupt the predicted binding site of miR-224-5p and increase the transcript levels of CAV2. The association of the rs1052990 minor allele with increased expression levels of CAV2 has been reported previously.55 In addition, both miR-224-5p and CAV2 are expressed in the eye.56,57 These data may suggest an allele-specific regulation of CAV2 by miR-224-5p as a functional mechanism underlying the observed GWAS association.